2',3'-cGAMP 就會(huì)與銜接蛋白 STING(干擾素基因刺激物)結(jié)合并觸發(fā)下游信號(hào)通路,從而產(chǎn)生 I 型干擾素和其他細(xì)胞因子,
Ex (nm) | - | Em (nm) | - |
分子量 | N/A | 溶劑 | DMSO |
存儲(chǔ)條件 | 在零下15度以下保存, 避免光照 |
產(chǎn)品基本信息
產(chǎn)品名稱:2',3'-cGAMP 馬來酰亞胺
儲(chǔ)存條件:-15℃避光防潮
保質(zhì)期:12個(gè)月
產(chǎn)品物理化學(xué)光譜特性
分子量:1156.10
外觀:固體
溶劑:DMSO
激發(fā)波長(nm):NA
發(fā)射波長(nm):NA
2',3'-cGAMP 馬來酰亞胺是一種出色的試劑,可將 2',3'-cGAMP 共價(jià)結(jié)合到含硫醇或硫醇修飾的生物靶標(biāo),例如蛋白質(zhì)、肽和核酸。 2',3'-cGAMP 近年來因其作為癌癥和病毒感染等病癥醫(yī)療靶點(diǎn)的潛力而受到廣泛關(guān)注。它已被證明可以激活免yi系統(tǒng)并增強(qiáng)免yi檢查點(diǎn)抑制劑的功效,這是一種癌癥免yi療法。 2',3'-cGAMP(環(huán)狀 GMP-AMP)是一種環(huán)狀二核苷酸二信使分子,在先天免yi系統(tǒng)中起著至關(guān)重要的作用。它由酶 cGAS(環(huán)狀 GMP-AMP 合酶)合成,以響應(yīng)從受損或感染細(xì)胞中釋放的胞質(zhì) DNA。一旦合成,2',3'-cGAMP 就會(huì)與銜接蛋白 STINGyi干擾素基因刺激物)結(jié)合并觸發(fā)下游信號(hào)通路,從而產(chǎn)生 I 型干擾素和其他細(xì)胞因子,從而導(dǎo)致針對(duì)入侵病原體的免yi反應(yīng)。
參考文獻(xiàn)
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